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Thiazolidinediones (TZDs): Mechanism & Side Effects | Part 2
TZDs activate a nuclear receptor called PPAR-γ (Peroxisome Proliferator-Activated Receptor-gamma) found mainly in adipose tissue, liver, and skeletal muscle. Activation leads to: Increased GLUT-4 expression → ↑ Glucose uptake Increased Adiponectin → ↑ Insulin sensitivity Reduced Insulin resistance Improved fat and glucose metabolism ...
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