11 M. S. van der Knaap, M.D., Ph.D. 1VU University Medical Center, Amsterdam, Netherlands The brain is an organ with a highly complex functional topography. Different areas have …

ter lamella of the subcortical white matter (1, 5, 9, 10). Clinically van der Knaap's disease is characterized by an abnormally enlarged head appearing in infancy, mild motor developmental …

Magnetic Resonance of Myelination and Myelin Disorders, 3rd ed Marjo S. van der Knaap and Jaap Valk, eds. New York: Springer; 2005, 1084 pages, 3873 illustrations, $499.

Here we present a case of a macrocephalic 4 month old female with infantile seizures with follow up at 8 months of age, having typical MRI findings of Van der Knaap disease and symptomatic …

Abstract Megalencephalic leukoencephalopathy (MLC) with subcortical cysts, or Van der Knaap disease, is a very rare genetic disorder afecting the white matter. The clinical presentation is …

We observed several patients with a clinical and MRI phenotype suggestive of an infantile onset peroxi-somal defect, but no convincing abnormalities in initial peroxisomal blood tests. Brain …

Dec 18, 2023 · This case shows the importance of the clinical and radiological features of Van der Knaap's disease, a rare leukodystrophy affecting the white matter of the brain with …