Pyruvate dehydrogenase complex (PDC) is a complex of three enzymes that converts pyruvate into acetyl-CoA by a process called pyruvate decarboxylation. [1] Acetyl-CoA may then be …

In mammals, PDC plays the role of a gatekeeper in the metabolism of pyruvate to maintain glucose homeostasis during the fed and fasting states. The flux through PDC is tightly …

Apr 29, 2025 · Explore the structure, function, and regulation of the pyruvate dehydrogenase complex, highlighting its enzymatic components and role in cellular metabolism.

4 days ago · The Pyruvate Dehydrogenase and TCA cycle page details the pyruvate dehydrogenase (PDH) reaction and the pathway for oxidation of acetyl-CoA.

The pyruvate dehydrogenase complex (PDHc) is a mitochondrial matrix multienzyme complex that provides the link between glycolysis and the tricarboxylic acid (TCA) cycle by catalyzing …

Pyruvate dehydrogenase deficiency (PDHD) is a rare neurometabolic disorder characterized by a wide range of clinical signs with metabolic and neurological components of varying severity. …

The pyruvate dehydrogenase complexes (PDCs) from all known living organisms comprise three principal catalytic com-ponents for their mission: E1 and E2 generate acetyl-coenzyme A, …

Pyruvate dehydrogenase is usually encountered as a component, referred to as E1, of the pyruvate dehydrogenase complex (PDC). PDC consists of other enzymes, referred to as E2 …

A combination of crystallography, NMR spectroscopy and electron microscopy is revealing the secrets of pyruvate dehydrogenase complex. The complex performs a central step in energy …

It is catalyzed by the pyruvate dehydrogenase complex (PDH). This process produces one NADH electron carrier while releasing a CO 2 molecule. This step is also known as the link reaction …