Janus kinase inhibitor - Wikipedia
Janus kinase inhibitor ... A Janus kinase inhibitor, also known as JAK inhibitor or jakinib, [1] is a type of immune modulating medication, which inhibits the activity of one or more of the Janus kinase family …
What are JAK inhibitors and how do they work? - Drugs.com
Jul 15, 2025 · Janus kinase (JAK) inhibitors are a group of medicines that help block immune system signals in the body that can lead to swelling (inflammation) and pain in conditions like rheumatoid …
JAK Inhibitors: Uses, Types, Side Effects, and More
Aug 23, 2025 · In this article, learn about the dosage, uses, and ongoing research underway for JAK inhibitors available in the United States, as well as common side effects, contraindications, and …
JAK inhibitors: an evidence-based choice of the most appropriate ...
Recently, Janus kinase inhibitors (JAKi) have been developed to block the effect of proinflammatory cytokines in IMIDs.
JAK Inhibitors 101 - The Rheumatologist
Jul 28, 2025 · The JAK-signal transducer and activator of transcription (STAT) pathway is central to immune dysregulation in many autoimmune diseases due to its role in transducing signals from an …
JAK Inhibitors — More Than Just Glucocorticoids | NEJM
Jul 28, 2021 · Janus kinase (JAK) inhibitors constitute further weapons in the armamentarium here. Two randomized trials have evaluated the efficacy of the JAK inhibitors ruxolitinib and baricitinib in...
JAK inhibitors (JAKi): Mechanisms of action and perspectives in ...
Feb 1, 2025 · Understanding the cell signaling pathway, and more specifically the JAK STAT pathway, is a breakthrough in the era of biotherapies. JAKi are increasingly designed to target a single JAK …
The JAK/STAT signaling pathway: from bench to clinic
Nov 26, 2021 · When cytokines bind to their receptors, JAK tyrosine kinases are activated and transmit regulatory signals. The JAK family has four main members, JAK1, JAK2, JAK3, and TYK2.
List of the 9 Leading JAK Inhibitor Drugs - GoodRx
Aug 13, 2024 · JAK inhibitors like Xeljanz, Rinvoq, and Opzelura can treat inflammatory conditions and even alopecia. View this list of JAK inhibitors to learn about their various uses.
JAK inhibitors—Friend or Foe? - The Lancet Rheumatology
The licensing of Janus kinase (JAK) inhibitors for patients with rheumatic disease marked a pivotal moment in the pursuit of new groundbreaking therapies for patients.