Caspase - Wikipedia
For example, inflammatory caspase-1 has been implicated in causing autoimmune diseases; drugs blocking the activation of Caspase-1 have been used to improve the health of patients. Additionally, …
Caspases: structural and molecular mechanisms and functions in cell ...
May 5, 2025 · Traditionally, caspases are classified as either apoptotic (caspase-2, -3, -6, -7, -8, -9, and -10) or inflammatory (caspase-1, -4, -5, and -11).
Caspase Functions in Cell Death and Disease - PMC
Accordingly, caspases have been broadly classified by their known roles in apoptosis (caspase-3, -6, -7, -8, and -9 in mammals), and in inflammation (caspase-1, -4, -5, -12 in humans and caspase-1, -11, …
What Are Caspases and What Do They Do? - Biology Insights
Jul 24, 2025 · Caspase activation in programmed cell death unfolds through a coordinated cascade. Caspases are initially present in cells as inactive precursors called procaspases.
A Review on Caspases: Key Regulators of Biological Activities and ...
Caspases have been broadly classified by their known roles in apoptosis (caspase-3, caspase-6, caspase-7, caspase-8, and caspase-9 in mammals) and in inflammation (caspase-1, caspase-4, …
Caspase - an overview | ScienceDirect Topics
Therapeutic interventions that involve the caspase cascade have long been a goal of many pharmaceutical companies because dysregulated caspase activity (and therefore apoptosis) is an …
Caspase-3 cleaves and activates the NADase SARM1 to promote
Furthermore, we found that during apoptosis, the key apoptotic effector protease caspase-3 cleaves SARM1 in its ARM domain, derepressing its intramolecular autoinhibition and activating its NAD …
Human Caspases: Activation, Specificity, and Regulation
May 26, 2009 · Usually, caspases with a long prodomain (∼100 residues) activate by dimerization (inflammatory caspases, apical caspases, and caspase-2), whereas caspases with a short …
Caspase Functions in Cell Death and Disease - CSHL P
Accordingly, caspases have been broadly classified by their known roles in apoptosis (caspase-3, -6, -7, -8, and -9 in mammals), and in inflammation (caspase-1, -4, -5, -12 in humans and caspase-1, -11, …
Cell death mechanisms in heatstroke and sepsis: ZBP1 and caspase-11 …
Therefore, this review synthesizes recent research findings to analyze the convergent cellular programmed death mechanisms of these two distinct conditions from the perspectives of molecular …