CD3 is initially expressed in the cytoplasm of pro-thymocytes, the stem cells from which T-cells arise in the thymus. The pro-thymocytes differentiate into common thymocytes, and then into …

Nov 14, 2025 · The CD3 complex acts as the signal transducer, translating external recognition by the TCR into internal cellular action. The complex is composed of multiple protein chains, …

Aug 4, 2025 · CD3 (Cluster of Differentiation 3) is a protein complex found on the surface of T cells. It acts as a universal marker for T cells, used to identify and count T cells.

CD3 is part of the T-cell receptor (TCR) complex, which is essential for T-cell activation in response to antigens. When T-cells recognize a foreign pathogen, CD3 initiates a cascade of …

What is CD3? CD3 is a protein that is normally made by two types of specialized immune cells, T cells and NK cells. Most lymphomas that start from T and NK cells, including peripheral T cell …

Anti-CD3 antibodies act as potent immunosuppressive agents by modulating the CD3/T-cell receptor (TCR) complex. They have been used in patients to prevent short term allograft …

This mini-review explains the structure of CD3, the genes involved in its expression, its function and the signal transduction pathways mediated by CD3 complex.

In this review, we will focus on those strategies that directly target the CD3/TCR complex in situ—namely, CD3 specific antibodies, their variants, and CD3 aptamers (Table 1).

Jun 7, 2024 · CD3 is a protein complex found on the surface of T cells, a type of white blood cell that is central to the immune response. The CD3 complex is composed of several subunits: …

Mar 18, 2022 · CD3 is a cell surface complex composed of 4 distinct subunits; these subunits are chains of integral membrane glycoproteins that associate with T cell antigen receptor (TCR) …