This study provides a comprehensive evaluation of how the composition of immune landscape is altered in the aortic wall of diverse types of AD, and opens new avenues for a rational and precise anti-AD ...

A new 3D human brain tissue platform developed by MIT researchers is the first to integrate all major brain cell types, including neurons, glial cells and the vasculature into a single culture. Grown ...

Over the past decades, large-scale human genetic studies have identified numerous risk genes and variants associated with complex diseases and traits.

Dissociating tissues into single cells is a core laboratory technique and vital for widely used applications such as next-generation sequencing or flow cytometry. Scientists who employ tissue ...

Type 1 diabetes is a disease where the immune system destroys insulin-producing beta cells in pancreatic islets. About 2 million Americans have Type 1 diabetes. The islets of Langerhans are named for ...

A new study shows, for the first time, how the human genome folds and moves in 3D over time to control when genes turn on and ...

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One of the biggest quests in biology is understanding how every cell in an animal's body carries an identical genome yet ...

Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimislecel ...