Does depression have some hidden trigger? Although depression most often arises in response to some kind of defeat, depression can seem to arise out of the blue, for no obvious reason. It may even ...

Patients with type 2 diabetes often have comorbid major depressive disorder, but the underlying neurobiological substrates are still poorly understood. The goal of this study was, therefore, to ...

The core experiences of depression — changes in energy, activity, thinking, and mood — have been described for more than 10,000 years. The word “depression” has been used for about 350 years. Given ...

Depression has often been blamed on low levels of serotonin in the brain. That answer is insufficient, but alternatives are coming into view and changing our understanding of the disease. The ...

Since the 1960s, researchers have postulated that major depression stems from disruptions in the serotonin neurotransmitter system, but the evidence for that idea, though plentiful, was indirect. In ...

Depression is characterized by a persistent low mood that can affect quality of life. If symptoms usually only occur in the winter months, it may be seasonal affective disorder (SAD), or major ...

Although depression most often arises in response to some kind of defeat, depression can seem to arise out of the blue, for no obvious reason. It may even arise when life appears to be going extremely ...