The attachment of sister kinetochores to microtubules from opposite spindle poles is necessary for accurate chromosome segregation during cell division. Unattached kinetochores activate the cell-cycle ...

In human cells, lengthy strands of DNA have to be carefully organized and compacted so they'll fit into the nucleus; our genome is arranged into chromosomes that have to be duplicated each time a cell ...

Thousands of our cells successfully divide every day. They replicate their DNA and then separate so that each of the new cells has the same complement of chromosomes. If the process goes wrong and ...

(Phys.org) -- With the first-ever three-dimensional image of an isolated kinetochore – the bulky molecular machine that connects a chromosome to the long, thin microtubules that tug it to one end of a ...

Chromosome motions to the spindle midzone, or congression, is an efficient process in mitosis. After nuclear envelope breakdown (NEBD) at prometaphase, the kinetochore, an organelle at the centromere ...

The protein complex responsible for the distribution of chromosomes during cell division is assembled in the transition regions between heterochromatin and euchromatin. The centromere is a specialized ...

The cell cycle, the biological process underlying how cells grow and multiply, is tightly regulated to ensure a faithful distribution of genetic material to ‘daughter’ cells. This tight regulation of ...

Scientists report that two proteins once thought to have only supporting roles, are the true "stars" of the kinetochore assembly process in human cells. The kinetochore is vital to proper DNA ...

The kinetochore connects chromosomes to spindle microtubules, corrects attachment errors, and triggers the separation of sister chromatids. It is built from more than 100 proteins, grouped into around ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, No. 15 (Apr. 12, 2005), pp. 5408-5413 (6 pages) The budding yeast kinetochore is comprised of >60 proteins ...

Cell division builds our bodies, supplying all cells in our tissues and organs, from the skin to the intestine, from the blood to the brain. It not only allows these organs to grow, but also to ...