Kyle Miller and his team discovered a potential new target for drug therapies: structures in our DNA called R-loops. A human cancer cell that overexpresses the enzyme APOBEC3B (left) has fewer R-loops ...

Researchers at Baylor College of Medicine and collaborating institutions report in the journal Nature Communications how a mutation in the enzyme SKD3 can cause a form of a genetic disease known as ...

Over half of all the cancer genomes that researchers have sequenced share one characteristic: They contain mutational signatures associated with a family of enzymes called APOBEC3, suggesting a role ...

A research group led by the University of Osaka has discovered that the DNA repair enzyme Polβ plays a crucial role in protecting the developing brain from harmful mutations. The study found that a ...

This is a preview. Log in through your library . Abstract Mutations that cause neurological phenotypes are highly informative with regard to mechanisms governing human brain function and disease. We ...

An international research team has published a study in the journal The FEBS Journal that significantly advances the knowledge of a rare hereditary metabolic disease: classical homocystinuria. The ...

This time, that direction was artificial intelligence. Warshel's first AI-based effort focused on trying to predict how mutations in enzymes alter their activity. In the case of viruses like HIV, ...

Prof. Lukas Dow, biochemistry, and his team published a study in Nature on Aug. 16, detailing a new, more specific gene editing tool that they created to study cancer mutations through preclinical ...

Researchers identify the PKC-alpha enzyme as a promising therapeutic target in Alzheimer's disease; a mutation that increases its activity led to biochemical, cellular and cognitive impairments in ...

A research group led by The University of Osaka has discovered that the DNA repair enzyme Polβ plays a crucial role in protecting the developing brain from harmful mutations. The study found that a ...