Centrosome separation represents an inaugural step in the entry into mitosis. In many organisms centrosome separation and bipolar spindle formation are driven by the action of molecular motors, namely ...
Centrosomes serve as microtubule organizing centres in animal cells and have a key role in organizing the mitotic spindle. Efficient bipolar spindle assembly requires coordination of centrosome and ...
Mechanistic model for MTOC maturation in GV oocytes. The MTOC (grey) activates near the oocyte cortex, which requires recruitment of CKAP5 and TACC3. After activation, MTOC migrates to the nuclear ...
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